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KMID : 0603520020070010019
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Journal of Korean Association of Cancer Prevention
2002 Volume.7 No. 1 p.19 ~ p.26
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Regulation of Angiogenic Activity of Insulin-like Growth Factor II (IGF-II) in Chick Chorioallantoic Membrane
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Bae Myung-Ho
Bae Soo-Kyung
Lee Ok-Hee
Kwon Yoo-Wook
Kim Moon-Bum
Oh Chang-Keun
Jang Ho-Sun
Kwon Kyung-Sool
Kim Kyu-Won
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Abstract
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Insulin-like growth factor II (IGF-II) is highly expressed during hepatocarcinogenesis and psoriasis. It has also angiogenic activity in quantiative chick chorioallantoic membrane (CAM) assay. However, the regulating factor of angiogenic activity of IGF-II is largely unknown. This study was undertaken to examine the control mechanism of angiogenic activity of IGF-II during the development of hepatocellular carcinoma and psoriasis. In this study, we examined angiogenic activity of IGF-II within HepG2 con-ditioned media by immunoprecipitaion and CAM assay. The EGF potentiated the angiogenic activity of IGF-II synergistically while heparin had no effect on the angiogenic activity of IGF-II. This effect of EGF may due to increased-activity of endothelial cell migration. However, EGF had no effect on the proliferating activity of endothelial cells. Finally, we demonstrated that IGF-IIR induced the expression of IGF-II. These results may examine the development mechanism of the hepatocellular carcinoma and psoriasis.
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KEYWORD
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Insulin like growth factor-II, Angiogenesis, Endothelial cell, Psoriasis
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